NFL Week 4 picks, predictions, schedule, odds, fantasy tips

Key Points:

• Week 4 of the 2026 NFL season features key quarterback matchups including Joe Burrow vs. Trevor Lawrence, Drake Maye vs. Josh Allen, and Matthew Stafford vs. Jalen Hurts, alongside divisional games like Chiefs vs. Raiders and an NFC South Monday night clash between Falcons and Saints.
• The Colts face the Commanders in London with the Colts' defense giving up the most yards in the NFL, while Commanders' run defense ranks third; experts predict a close game with a slight edge to the Colts.
• The Jaguars visit the Bengals in a potential playoff preview, highlighting the matchup between Bengals' Joe Burrow and Jaguars' Trevor Lawrence; Bengals are favored but the game is expected to be competitive.
• The Cowboys and Texans play a crucial game with both teams struggling early; Cowboys aim to rebound from a tough start while Texans look to get star WR Nico Collins back, with predictions favoring a narrow Cowboys win.
• The Patriots visit the undefeated Bills in a divisional battle where the Bills' strong offensive line and Josh Allen's dual-threat ability are key; the Bills are heavy favorites despite the Patriots' defensive efforts.
• Other notable games include Rams vs. Eagles with Rams' Aaron Donald's health in question, Jets vs. Bears featuring Jets QB Geno Smith's hot start, and Vikings vs. Dolphins with Vikings' aggressive blitz defense facing a struggling Dolphins offense.