Patriots vs. Seahawks prediction, odds, time: 2026 NFL Kickoff Game picks

Key Points:

• The 2026 NFL Kickoff Game will feature a rematch of the Super Bowl, with the Seattle Seahawks hosting the New England Patriots on Wednesday, September 9, marking the second time the game is not on a Thursday.
• Both teams finished the previous season with 14-3 records, with Seattle winning the Super Bowl 29-13 over New England; Patriots running back TreVeyon Henderson is ruled out due to an ankle injury.
• The game is set for 8:20 p.m. ET at Lumen Field, with Seattle favored by 3 points and an over/under of 44.5 points; betting models strongly favor the Over based on offensive upgrades and recent scoring trends.
• A SportsLine projection model, which has a strong track record with NFL picks, predicts the total points will exceed 44.5, projecting around 46 combined points due to both teams' potent offenses and historical scoring patterns.
• The model also indicates a strong betting edge on one side of the spread with over 60% confidence, encouraging bettors to consult the model’s detailed picks before placing wagers.