Spain vs. Portugal prediction, odds, line, start time: 2026 World Cup Round of 16 picks
Key Points:
- Spain and Portugal will face each other in the Round of 16 at the 2026 World Cup, marking their third World Cup meeting after over 40 previous encounters.
- Spain, led by Lamine Yamal, won their first knockout match 3-0 against Austria, while Portugal, powered by Cristiano Ronaldo, edged Croatia 2-1 in the Round of 32.
- The winner of this derby will face the victor of the USA vs. Belgium match next.
- Betting odds favor Spain slightly, with a 90-minute money line at -110, Portugal at +310, and a draw at +250; the over/under for total goals is set at 2.5.
- Expert bettor Jon Eimer recommends backing the Over 2.5 total goals based on recent high-scoring encounters between the teams and their offensive form in the tournament.