Successful 40-Hz auditory stimulation in aged monkeys suggests potential for noninvasive Alzheimer's therapy
Medical Xpress••health
Key Points:
- Researchers at the Kunming Institute of Zoology demonstrated that 40-Hz auditory stimulation significantly increases β-amyloid levels in the cerebrospinal fluid of aged rhesus monkeys, with effects lasting over five weeks.
- The study used nine aged rhesus macaques, which naturally develop amyloid plaques similar to human Alzheimer's disease, making them a relevant model for translational research.
- After seven days of daily one-hour 40-Hz auditory stimulation, key β-amyloid proteins Aβ42 and Aβ40 in CSF increased by over 200%, supporting the idea that this stimulation promotes β-amyloid clearance from the brain.
- The sustained elevation of β-amyloid levels five weeks post-treatment is a novel
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