Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

Key Points:

• The Rams and 49ers, both returning from playing in Australia, have favorable home games in Week 2, with the 49ers favored by 13.5 points and the Rams by 7.5 points despite some player uncertainties.
• SportsLine’s advanced computer model, which simulates each NFL game 10,000 times, has a strong track record with over $7,000 in returns for $100 bettors since 2024 and is providing updated Week 2 picks and betting advice.
• Key model predictions include the Seahawks covering a 4-point spread against the Cardinals, leveraging their historical dominance and rest advantage, and the Buccaneers expected to cover an 8.5-point spread versus the Browns, who struggled significantly in Week 1.
• The model also identifies an underdog expected to win outright by a touchdown, offering potential for a significant payout, with all picks and detailed betting lines available exclusively on SportsLine.
• Bettors are encouraged to use promo codes like CBSSPORTS for bonuses on platforms such as Polymarket and Kalshi to enhance their sports trading experience this NFL season.