Week 4 NFL odds, predictions: Picks from 10,000 computer simulations
Key Points:
- Week 4 of the NFL features 16 games before byes begin in Week 5, including the league's first London game with the Colts favored by 3.5 points over the Commanders.
- Key divisional matchups include Patriots vs. Bills (Bills favored by 6.5), Chiefs vs. Raiders (Chiefs favored by 4.5), and Monday's Saints vs. Falcons game, which marks the 20th anniversary of the 2006 "Domecoming."
- Heavy favorites this week are the Ravens (-11.5) against the winless Titans and the Vikings (-10.5) over the 0-3 Dolphins, according to updated betting lines.
- SportsLine's advanced computer model, which has a strong track record with over $7,000 in returns for $100 bettors since 2024, recommends the Giants (+1.5) to cover against the Cardinals and the Seahawks (-7) to cover versus the Chargers.
- The model also highlights five teams projected to win by double digits, offering potential value on alternate lines, with all picks and detailed betting advice available at SportsLine.