How to watch Rams vs. Bills: Prediction, odds, pick, time for Monday Night Football

Key Points:

• The Los Angeles Rams (2-2) host the Buffalo Bills (3-1) in Week 5 of Monday Night Football, with the Rams aiming to improve to a winning record and the Bills seeking to bounce back from their first loss of the season.
• The Rams have shown strong defensive performances recently, holding opponents under 260 yards in their last three games and benefiting from the return of Aaron Donald, while the Bills' offense has struggled with turnovers and injuries to key receivers Josh Palmer and possibly DJ Moore.
• Buffalo's offense, led by quarterback Josh Allen, faces challenges due to a potentially depleted receiving corps and a tough Rams pass defense that has limited tight ends effectively; running back James Cook's performance will be crucial to alleviating pressure on the passing game.
• On offense, the Rams have gained over 415 yards in each of their last three games but have been hampered by turnovers and a dip in quarterback Matthew Stafford's efficiency compared to his MVP season.
• Buffalo's defense has been vulnerable against the pass, giving up significant yardage and touchdowns, while the Rams' running backs Kyren Williams and Blake Corum have been highly efficient and could exploit the Bills' high missed-tackle rate.