Week 1 NFL odds, picks, predictions: Computer model backs Eagles and Jaguars

Key Points:

• The NFL's Week 1 schedule features high-profile matchups including Chiefs vs. Broncos, Cowboys vs. Giants, and Cardinals vs. Chargers with notable betting lines and player debuts to watch.
• The Dolphins vs. Raiders game is unique as both teams will start new quarterbacks, with Miami's Malik Willis facing off against Kirk Cousins, while the Raiders will miss star tight end Brock Bowers due to injury.
• SportsLine’s advanced computer model, which simulates each NFL game 10,000 times, has a strong track record with over $7,000 in returns since 2024 and is providing betting picks for all Week 1 matchups.
• Top model picks include Jacksonville Jaguars (-8.5) expected to cover at home against Cleveland, and Philadelphia Eagles (-5.5) predicted to cover versus the Washington Commanders, based on team performance trends and player availability.
• Bettors are encouraged to visit SportsLine for detailed predictions on every Week 1 game, including underdog picks with potential for significant payouts, supported by the model's proven success.