Ozempic and Wegovy may cause rare brain disorder, new study warns
Key Points:
- Researchers have identified 15 cases of Wernicke encephalopathy, a rare but serious brain condition caused by severe vitamin B1 deficiency, in people taking GLP-1 receptor agonist weight-loss medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound).
- Most affected patients experienced gastrointestinal symptoms such as nausea, vomiting, weight loss, and malnutrition, which may contribute to vitamin B1 deficiency; however, the study cannot definitively link the medications as the cause.
- Experts emphasize that while the condition is rare among millions using these drugs, it is serious and may result from reduced appetite and nutrient intake caused by GLP-1 medications.
- Individuals with persistent nausea, rapid weight loss, history of bariatric surgery, or heavy alcohol use may be at higher risk, and proper nutrition and hydration are crucial during treatment.
- Researchers call for further investigation but advise patients not to discontinue prescribed GLP-1 medications without consulting their healthcare provider.