Widely used pesticide linked to more than doubled Parkinson's risk
Medical Xpress••health
Key Points:
- A UCLA Health study found that long-term residential exposure to the pesticide chlorpyrifos increases the risk of developing Parkinson's disease by more than 2.5 times, supported by both human data and laboratory experiments.
- The research demonstrated that chlorpyrifos damages dopamine-producing neurons, causes brain inflammation, and leads to abnormal alpha-synuclein accumulation, key features of Parkinson's disease.
- Experiments in mice and zebrafish revealed that chlorpyrifos disrupts autophagy, a cellular cleanup process, and restoring this process or removing synuclein protein protected neurons from damage.
- Although residential use of chlorpyrifos was banned in 2001 and restricted in agriculture in 202
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